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Dokumenttyp:
journal article 
Autor(en):
Weis, S; Jesinghaus, M; Kovacs, P; Schleinitz, D; Schober, R; Ruffert, C; Herms, M; Wittenburg, H; Stumvoll, M; Blüher, M; Grützmann, R; Schulz, HU; Keim, V; Mössner, J; Bugert, P; Witt, H; Drenth, JP; Krohn, K; Rosendahl, J 
Titel:
Genetic analyses of heme oxygenase 1 (HMOX1) in different forms of pancreatitis. 
Abstract:
Heme oxygenase 1 (HMOX1) is the rate limiting enzyme in heme degradation and a key regulator of inflammatory processes. In animal models the course of pancreatitis was ameliorated by up-regulation of HMOX1 expression. Additionally, carbon monoxide released during heme breakdown inhibited proliferation of pancreatic stellate cells and might thereby prevent the development of chronic pancreatitis (CP). Transcription of HMOX1 in humans is influenced by a GT-repeat located in the promoter. As such,...    »
 
Zeitschriftentitel:
PLoS ONE 
Jahr:
2012 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
e37981 
Sprache:
eng 
TUM Einrichtung:
Kinderklinik und Poliklinik