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Autor(en):
Rinck, A.; Preusse, M.; Laggerbauer, B.; Lickert, H.; Engelhardt, S.; Theis, F. J. 
Titel:
The human transcriptome is enriched for miRNA-binding sites located in cooperativity-permitting distance 
Abstract:
Heat denaturation of native phages SD suspensions, phage 'shadows', and isolated phage DNA solutions were studied by scanning microcalorimetry and viscosimetry. Energetic parameters of cooperative transitions of protein fraction and DNA were measured. DNA melting was shown to be preceded by the destruction of capsid and protein denaturation. The melting curve of isolated DNA and DNA in the presence of protein component is characterized by a fine structure which is completely restored at repeated...    »
 
Stichworte:
cooperativity microRNA target prediction target regulation 
Zeitschriftentitel:
RNA Biol. 
Jahr:
2013 
Band / Volume:
10 
Heft / Issue:
Seitenangaben Beitrag:
1125-1135