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Author(s):
Moignard, V.; Macaulay, I. C.; Swiers, G.; Buettner, F.; Schütte, J.; Calero-Nieto, F. J.; Kinston, S.; Joshi, A.; Hannah, R.; Theis, F. J.; Jacobsen, S. E.; de Bruijn, M. F.; Gottgens, B. 
Title:
Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis 
Abstract:
Cellular decision-making is mediated by a complex interplay of external stimuli with the intracellular environment, in particular transcription factor regulatory networks. Here we have determined the expression of a network of 18 key haematopoietic transcription factors in 597 single primary blood stem and progenitor cells isolated from mouse bone marrow. We demonstrate that different stem/progenitor populations are characterized by distinctive transcription factor expression states, and through...    »
 
Journal title:
Nat. Cell Biol. 
Year:
2013 
Journal volume:
15 
Journal issue:
Pages contribution:
363-372