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Author(s):
Krumsiek, J.; Marr, C.; Schroeder, T.; Theis, F. J. 
Title:
Hierarchical differentiation of myeloid progenitors is encoded in the transcription factor network 
Abstract:
Hematopoiesis is an ideal model system for stem cell biology with advanced experimental access. A systems view on the interactions of core transcription factors is important for understanding differentiation mechanisms and dynamics. In this manuscript, we construct a Boolean network to model myeloid differentiation, specifically from common myeloid progenitors to megakaryocytes, erythrocytes, granulocytes and monocytes. By interpreting the hematopoietic literature and translating experimental ev...    »
 
Keywords:
hematopoietic stem-cells lineage-commitment factor gata-1 c/ebp-alpha mice lacking regulatory networks logical analysis mouse embryos fetal liver factor eklf 
Journal title:
PLoS One 
Year:
2011 
Journal volume:
Journal issue: