Benutzer: Gast  Login
Autor(en):
Konopka, W.; Kiryk, A.; Novak, M.; Herwerth, M.; Parkitna, J. R.; Wawrzyniak, M.; Kowarsch, A.; Michaluk, P.; Dzwonek, J.; Arnsperger, T.; Wilczynski, G.; Merkenschlager, M.; Theis, F. J.; Köhr, G.; Kaczmarek, L.; Schütz, G. 
Titel:
MicroRNA loss enhances learning and memory in mice 
Abstract:
Dicer-dependent noncoding RNAs, including microRNAs (miRNAs), play an important role in a modulation of translation of mRNA transcripts necessary for differentiation in many cell types. In vivo experiments using cell type-specific Dicer1 gene inactivation in neurons showed its essential role for neuronal development and survival. However, little is known about the consequences of a loss of miRNAs in adult, fully differentiated neurons. To address this question, we used an inducible variant of th...    »
 
Stichworte:
Long-term potentiation dendritic spine morphogenesis synaptic plasticity protein-synthesis Messenger-RNÀ Matrix-metalloproteinase-9 Neurons Dicer Absence Neurodegeneration 
Zeitschriftentitel:
J. Neurosci. 
Jahr:
2010 
Band / Volume:
30 
Heft / Issue:
44 
Seitenangaben Beitrag:
14835-14842