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Autor(en):
Hock, S.; Ng, Y. K.; Hasenauer, J.; Wittmann, D. M.; Lutter, D.; Trümbach, D.; Wurst, W.; Prakash, N.; Theis, F. J. 
Titel:
Sharpening of expression domains induced by transcription and microRNA regulation within a spatio-temporal model of mid-hindbrain boundary formation 
Abstract:
BACKGROUND: The establishment of the mid-hindbrain region in vertebrates is mediated by the isthmic organizer, an embryonic secondary organizer characterized by a well-defined pattern of locally restricted gene expression domains with sharply delimited boundaries. While the function of the isthmic organizer at the mid-hindbrain boundary has been subject to extensive experimental studies, it remains unclear how this well-defined spatial gene expression pattern, which is essential for proper isthm...    »
 
Stichworte:
Mid-Hindbrain Boundary miRNA Modeling Spatio-temporal Model Developmental Biology 
Zeitschriftentitel:
BMC Syst. Biol. 
Jahr:
2013 
Band / Volume: