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Franke, R.; Theis, F. J.; Klamt, S. 
From binary to multivalued to continuous models: The lac operon as a case study 
Using the lac operon as a paradigmatic example for a gene regulatory system in prokaryotes, we demonstrate how qualitative knowledge can be initially captured using simple discrete (Boolean) models and then stepwise refined to multivalued logical models and finally to continuous (ODE) models. At all stages, signal transduction and transcriptional regulation is integrated in the model description. We first show the potential benefit of a discrete binary approach and discuss then problems and limi...    »
Journal title:
J. Integr. Bioinform. 
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