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Autor(en):
Breindl, C.; Waldherr, S.; Wittmann, D. M.; Theis, F. J.; Allgoewer, F. 
Titel:
Steady-state robustness of qualitative gene regulation networks 
Abstract:
In this paper, we define a robustness measure for gene regulation networks, which allows to quantify how well a given model structure can reproduce a desired steady-state pattern in the absence of detailed knowledge about the kinetic mechanisms and parameters. To develop this measure, a modeling framework is introduced, which is able to represent the qualitative knowledge typically available for gene regulation networks. With this framework, the robustness measure as well as tools for its effici...    »
 
Stichworte:
gene regulation networks qualitative modeling multistability robustness convex optimization mid-hindbrain boundary 
Zeitschriftentitel:
Int. J. Robust Nonlin. 
Jahr:
2011 
Band / Volume:
21 
Heft / Issue:
15 
Seitenangaben Beitrag:
1742-1758