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Autor(en):
Andres, C.; Hasenauer, J.; Ahn, H. S.; Joseph, E. K.; Isensee, J.; Theis, F. J.; Allgöwer, F.; Levine, J. D.; Dib-Hajj, S. D.; Waxman, S. G.; Hucho, T. 
Titel:
Wound-healing growth factor, basic FGF, induces Erk1/2-dependent mechanical hyperalgesia 
Abstract:
Growth factors such as nerve growth factor and glial cell line-derived neurotrophic factor are known to induce pain sensitization. However, a plethora of other growth factors is released during inflammation and tissue regeneration, and many of them are essential for wound healing. Which wound-healing factors also alter the sensitivity of nociceptive neurons is not well known. We studied the wound-healing factor, basic fibroblast growth factor (bFGF), for its role in pain sensitization. Reverse t...    »
 
Stichworte:
Pain Nociception Peripheral Sensory Neuron Sensitization Signaling Inflammatory Pain Wound Healing Quantitative Automated Microscopy Bfgf Fgf-2 Fgf-beta Map Kinase Erk1/2 Na(v)1.8 Voltage Gated Sodium Channels Randall Selitto 
Zeitschriftentitel:
Pain 
Jahr:
2013 
Band / Volume:
154 
Heft / Issue:
10 
Seitenangaben Beitrag:
2216-2226