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Dokumenttyp:
journal article 
Autor(en):
Huang, LR; Gäbel, YA; Graf, S; Arzberger, S; Kurts, C; Heikenwalder, M; Knolle, PA; Protzer, U 
Titel:
Transfer of HBV genomes using low doses of adenovirus vectors leads to persistent infection in immune competent mice. 
Abstract:
Studies of mechanisms responsible for the persistence of hepatitis B virus (HBV) infection have been hindered by a lack of appropriate animal models. HBV genomes can be delivered to livers of mice using hydrodynamic injection or high doses of an adenoviral vector; these lead to clearance of HBV. We found that infection of immunocompetent mice with low doses of an adenoviral vector resulted in persistent HBV infection; the mice neither underwent seroconversion to production of antibodies agains...    »
 
Zeitschriftentitel:
Gastroenterology 
Jahr:
2012 
Band / Volume:
142 
Heft / Issue:
Seitenangaben Beitrag:
1447-1450.e3 
Sprache:
eng 
Print-ISSN:
0016-5085 
TUM Einrichtung:
r Virologie