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Document type:
journal article 
Author(s):
Zhao, YD; Cai, L; Mirza, MK; Huang, X; Geenen, DL; Hofmann, F; Yuan, JX; Zhao, YY 
Title:
Protein kinase G-I deficiency induces pulmonary hypertension through Rho A/Rho kinase activation. 
Abstract:
Protein kinase G (PKG) plays an important role in the regulation of vascular smooth cell contractility and is a critical mediator of nitric oxide signaling, which regulates cardiovascular homeostasis. PKG-I-knockout (Prkg1(-/-)) mice exhibit impaired nitric oxide/cGMP-dependent vasorelaxation and systemic hypertension. However, it remains unknown whether PKG-I deficiency induces pulmonary hypertension. In this study, we characterized the hypertensive pulmonary phenotypes in Prkg1(-/-) mice and d...    »
 
Journal title abbreviation:
Am J Pathol 
Year:
2012 
Journal volume:
180 
Journal issue:
Pages contribution:
2268-75 
Language:
eng 
Print-ISSN:
0002-9440 
TUM Institution:
Institut für Pharmakologie und Toxikologie