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Document type:
journal article 
Author(s):
Harder, J; Ihorst, G; Heinemann, V; Hofheinz, R; Moehler, M; Buechler, P; Kloeppel, G; Röcken, C; Bitzer, M; Boeck, S; Endlicher, E; Reinacher-Schick, A; Schmoor, C; Geissler, M 
Title:
Multicentre phase II trial of trastuzumab and capecitabine in patients with HER2 overexpressing metastatic pancreatic cancer. 
Abstract:
Background:New therapeutic options for metastatic pancreatic cancer are urgently needed. In pancreatic cancer, overexpression of the epidermal growth factor receptor 2 (HER2) has been reported in up to 45%. This multicentre phase II study investigated the efficacy and toxicity of the HER2 antibody trastuzumab combined with capecitabine in the patients with pancreatic cancer and HER2 overexpression.Methods:Primary endpoint was progression-free survival (PFS) after 12 weeks. A total of 212 patient...    »
 
Journal title abbreviation:
Br J Cancer 
Year:
2012 
Journal volume:
106 
Journal issue:
Pages contribution:
1033-8 
Language:
eng 
Print-ISSN:
0007-0920 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie