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Document type:
journal article 
Author(s):
Rauch, C; Seidl, C; Schlapschy, M; Skerra, A; Morgenstern, A; Bruchertseifer, F; Senekowitsch-Schmidtke, R 
Title:
High molecular mass radioimmunoconjugates are promising for intraperitoneal ?-emitter immunotherapy due to prolonged retention in the peritoneum. 
Abstract:
Therapeutic efficacy of intraperitoneal radioimmunotherapy is dependent on the time of retention of the radioimmunoconjugates within the peritoneal cavity. Therefore, the aim of this study was to investigate intraperitoneal retention of Fab, IgG and IgM radioimmunoconjugates.Female Balb/c mice were injected with 213Bi- or 111In-labeled IgM, IgG and recombinant Fab conjugates intraperitoneally or intravenously. At different time points after injection, whole body distribution of radionuclides was...    »
 
Journal title abbreviation:
Nucl Med Biol 
Year:
2012 
Journal volume:
39 
Journal issue:
Pages contribution:
617-27 
Language:
eng 
Print-ISSN:
0969-8051 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik