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Dokumenttyp:
journal article 
Autor(en):
Feuerecker, B; Pirsig, S; Seidl, C; Aichler, M; Feuchtinger, A; Bruchelt, G; Senekowitsch-Schmidtke, R 
Titel:
Lipoic acid inhibits cell proliferation of tumor cells in vitro and in vivo. 
Abstract:
Cancer cells convert glucose preferentially to lactate even in the presence of oxygen (aerobic glycolysis-Warburg effect). New concepts in cancer treatment aim at inhibition of aerobic glycolysis. Pyruvate dehydrogenase converts pyruvate to acetylCoA thus preventing lactate formation. Therefore, the aim of this study was to evaluate compounds that could activate pyruvate dehydrogenase in cancer cells. We investigated the effects of (R)-(+)-?-lipoic acid (LPA) and dichloroacetate (DCA), possible...    »
 
Zeitschriftentitel:
Cancer Biol Ther 
Jahr:
2012 
Band / Volume:
13 
Heft / Issue:
14 
Seitenangaben Beitrag:
1425-35 
Sprache:
eng 
Print-ISSN:
1538-4047 
TUM Einrichtung:
Nuklearmedizinische Klinik und Poliklinik