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Document type:
journal article 
Author(s):
Kieseier, BC; Stüve, O; Dehmel, T; Goebels, N; Leussink, VI; Mausberg, AK; Ringelstein, M; Turowski, B; Aktas, O; Antoch, G; Hartung, HP 
Title:
Disease Amelioration With Tocilizumab in a Treatment-Resistant Patient With Neuromyelitis Optica: Implication for Cellular Immune Responses. 
Abstract:
BACKGROUND Neuromyelitis optica (NMO) is an autoimmune disease of the central nervous system in which aberrant antibody responses to the astrocytic water channel aquaporin 4 have been described. Experimental evidence is emerging that NMO is partly driven by the proinflammatory cytokine interleukin 6 (IL-6), which propagates the survival of disease-specific B cell subclasses, and deviates CD4+ T helper cell differentiation toward IL-17-producing T helper 17 cells. Tocilizumab is a recombinant hum...    »
 
Journal title abbreviation:
Arch Neurol 
Year:
2012 
Pages contribution:
1-4 
Language:
eng 
Print-ISSN:
0003-9942 
TUM Institution:
Neurologische Klinik und Poliklinik