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Dokumenttyp:
journal article 
Autor(en):
Benkhoucha, M; Molnarfi, N; Santiago-Raber, ML; Weber, MS; Merkler, D; Collin, M; Lalive, PH 
Titel:
IgG glycan hydrolysis by EndoS inhibits experimental autoimmune encephalomyelitis. 
Abstract:
Studies in experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, have shown that B cells markedly influence the course of the disease, although whether their effects are protective or pathological is a matter of debate. EndoS hydrolysis of the IgG glycan has profound effects on IgG effector functions, such as complement activation and Fc receptor binding, suggesting that the enzyme could be used as an immunomodulatory therapeutic agent against IgG-mediated disease...    »
 
Zeitschriftentitel:
J Neuroinflammation 
Jahr:
2012 
Band / Volume:
Seitenangaben Beitrag:
209 
Sprache:
eng 
TUM Einrichtung:
Neurologische Klinik und Poliklinik