Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Pozzi, B; Amodio, S; Lucano, C; Sciullo, A; Ronzoni, S; Castelletti, D; Adler, T; Treise, I; Betsholtz, IH; Rathkolb, B; Busch, DH; Wolf, E; Fuchs, H; Gailus-Durner, V; de Angelis, MH; Betsholtz, C; Casola, S; Di Fiore, PP; Offenhäuser, N 
Titel:
The endocytic adaptor Eps15 controls marginal zone B cell numbers. 
Abstract:
Eps15 is an endocytic adaptor protein involved in clathrin and non-clathrin mediated endocytosis. In Caenorhabditis elegans and Drosophila melanogaster lack of Eps15 leads to defects in synaptic vesicle recycling and synapse formation. We generated Eps15-KO mice to investigate its function in mammals. Eps15-KO mice are born at the expected Mendelian ratio and are fertile. Using a large-scale phenotype screen covering more than 300 parameters correlated to human disease, we found that Eps15-KO mi...    »
 
Zeitschriftentitel:
PLoS ONE 
Jahr:
2012 
Band / Volume:
Heft / Issue:
11 
Seitenangaben Beitrag:
e50818 
Sprache:
eng 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene