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Document type:
journal article 
Author(s):
Locatelli, G; Wörtge, S; Buch, T; Ingold, B; Frommer, F; Sobottka, B; Krüger, M; Karram, K; Bühlmann, C; Bechmann, I; Heppner, FL; Waisman, A; Becher, B 
Title:
Primary oligodendrocyte death does not elicit anti-CNS immunity. 
Abstract:
Anti-myelin immunity is commonly thought to drive multiple sclerosis, yet the initial trigger of this autoreactivity remains elusive. One of the proposed factors for initiating this disease is the primary death of oligodendrocytes. To specifically test such oligodendrocyte death as a trigger for anti-CNS immunity, we inducibly killed oligodendrocytes in an in vivo mouse model. Strong microglia-macrophage activation followed oligodendrocyte death, and myelin components in draining lymph nodes mad...    »
 
Journal title abbreviation:
Nat Neurosci 
Year:
2012 
Journal volume:
15 
Journal issue:
Pages contribution:
543-50 
Language:
eng 
Print-ISSN:
1097-6256 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene