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Dokumenttyp:
journal article 
Autor(en):
Böttcher, RT; Stremmel, C; Meves, A; Meyer, H; Widmaier, M; Tseng, HY; Fässler, R 
Titel:
Sorting nexin 17 prevents lysosomal degradation of ?1 integrins by binding to the ?1-integrin tail. 
Abstract:
Integrin functions are controlled by regulating their affinity for ligand, and by the efficient recycling of intact integrins through endosomes. Here we demonstrate that the Kindlin-binding site in the ?1-integrin cytoplasmic domain serves as a molecular switch enabling the sequential binding of two FERM-domain-containing proteins in different cellular compartments. When ?1 integrins are at the plasma membrane, Kindlins control ligand-binding affinity. However, when they are internalized, Kindli...    »
 
Zeitschriftentitel:
Nat Cell Biol 
Jahr:
2012 
Band / Volume:
14 
Heft / Issue:
Seitenangaben Beitrag:
584-92 
Sprache:
eng 
Print-ISSN:
1465-7392 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene