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Dokumenttyp:
journal article 
Autor(en):
Krautler, NJ; Kana, V; Kranich, J; Tian, Y; Perera, D; Lemm, D; Schwarz, P; Armulik, A; Browning, JL; Tallquist, M; Buch, T; Oliveira-Martins, JB; Zhu, C; Hermann, M; Wagner, U; Brink, R; Heikenwalder, M; Aguzzi, A 
Titel:
Follicular dendritic cells emerge from ubiquitous perivascular precursors. 
Abstract:
The differentiation of follicular dendritic cells (FDC) is essential to the remarkable microanatomic plasticity of lymphoid follicles. Here we show that FDC arise from ubiquitous perivascular precursors (preFDC) expressing platelet-derived growth factor receptor ? (PDGFR?). PDGFR?-Cre-driven reporter gene recombination resulted in FDC labeling, whereas conditional ablation of PDGFR?(+)-derived cells abolished FDC, indicating that FDC originate from PDGFR?(+) cells. Lymphotoxin-?-overexpressing p...    »
 
Zeitschriftentitel:
Cell 
Jahr:
2012 
Band / Volume:
150 
Heft / Issue:
Seitenangaben Beitrag:
194-206 
Sprache:
eng 
Print-ISSN:
0092-8674 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene; r Virologie