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Dokumenttyp:
journal article 
Autor(en):
Stross, L; Günther, J; Gasteiger, G; Asen, T; Graf, S; Aichler, M; Esposito, I; Busch, DH; Knolle, P; Sparwasser, T; Protzer, U 
Titel:
Foxp3+ regulatory T cells protect the liver from immune damage and compromise virus control during acute experimental hepatitis B virus infection in mice. 
Abstract:
The strength of antiviral T cell responses correlates with clearance of hepatitis B virus (HBV) infection, but the immunological mechanisms mitigating or suppressing HBV-specific T cells are still poorly understood. In this study, we examined the role of CD4(+) Foxp3(+) regulatory T cells (Tregs) in a mouse model of acute HBV infection. We initiated HBV infection via an adenoviral vector transferring a 1.3-fold overlength HBV genome (AdHBV) into transgenic DEREG mice, where Tregs can be transien...    »
 
Zeitschriftentitel:
Hepatology 
Jahr:
2012 
Band / Volume:
56 
Heft / Issue:
Seitenangaben Beitrag:
873-83 
Sprache:
eng 
Print-ISSN:
0270-9139 
TUM Einrichtung:
r Virologie; r Allgemeine Pathologie und pathologische Anatomie; r Medizinische Mikrobiologie, Immunologie und Hygiene