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Dokumenttyp:
journal article 
Autor(en):
Vince, JE; Wong, WW; Gentle, I; Lawlor, KE; Allam, R; O'Reilly, L; Mason, K; Gross, O; Ma, S; Guarda, G; Anderton, H; Castillo, R; Häcker, G; Silke, J; Tschopp, J 
Titel:
Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation. 
Abstract:
Interleukin-1? (IL-1?) is a potent inflammatory cytokine that is usually cleaved and activated by inflammasome-associated caspase-1. To determine whether IL-1? activation is regulated by inhibitor of apoptosis (IAP) proteins, we treated macrophages with an IAP-antagonist "Smac mimetic" compound or genetically deleted the genes that encode the three IAP family members cIAP1, cIAP2, and XIAP. After Toll-like receptor priming, IAP inhibition triggered cleavage of IL-1? that was mediated not only by...    »
 
Zeitschriftentitel:
Immunity 
Jahr:
2012 
Band / Volume:
36 
Heft / Issue:
Seitenangaben Beitrag:
215-27 
Sprache:
eng 
Print-ISSN:
1074-7613 
TUM Einrichtung:
r Klinische Chemie und Pathobiochemie