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Dokumenttyp:
journal article 
Autor(en):
Sankaran, VG; Ludwig, LS; Sicinska, E; Xu, J; Bauer, DE; Eng, JC; Patterson, HC; Metcalf, RA; Natkunam, Y; Orkin, SH; Sicinski, P; Lander, ES; Lodish, HF 
Titel:
Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number. 
Abstract:
Genome-wide association studies (GWASs) have identified a genetic variant of moderate effect size at 6p21.1 associated with erythrocyte traits in humans. We show that this variant affects an erythroid-specific enhancer of CCND3. A Ccnd3 knockout mouse phenocopies these erythroid phenotypes, with a dramatic increase in erythrocyte size and a concomitant decrease in erythrocyte number. By examining human and mouse primary erythroid cells, we demonstrate that the CCND3 gene product cyclin D3 regula...    »
 
Zeitschriftentitel:
Genes Dev 
Jahr:
2012 
Band / Volume:
26 
Heft / Issue:
18 
Seitenangaben Beitrag:
2075-87 
Sprache:
eng 
Print-ISSN:
0890-9369 
TUM Einrichtung:
r Klinische Chemie und Pathobiochemie