User: Guest  Login
Document type:
journal article 
Author(s):
Sankaran, VG; Ludwig, LS; Sicinska, E; Xu, J; Bauer, DE; Eng, JC; Patterson, HC; Metcalf, RA; Natkunam, Y; Orkin, SH; Sicinski, P; Lander, ES; Lodish, HF 
Title:
Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number. 
Abstract:
Genome-wide association studies (GWASs) have identified a genetic variant of moderate effect size at 6p21.1 associated with erythrocyte traits in humans. We show that this variant affects an erythroid-specific enhancer of CCND3. A Ccnd3 knockout mouse phenocopies these erythroid phenotypes, with a dramatic increase in erythrocyte size and a concomitant decrease in erythrocyte number. By examining human and mouse primary erythroid cells, we demonstrate that the CCND3 gene product cyclin D3 regula...    »
 
Journal title abbreviation:
Genes Dev 
Year:
2012 
Journal volume:
26 
Journal issue:
18 
Pages contribution:
2075-87 
Language:
eng 
Print-ISSN:
0890-9369 
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie