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Dokumenttyp:
journal article 
Autor(en):
Liu, Q; Yuan, B; Lo, KA; Patterson, HC; Sun, Y; Lodish, HF 
Titel:
Adiponectin regulates expression of hepatic genes critical for glucose and lipid metabolism. 
Abstract:
The effects of adiponectin on hepatic glucose and lipid metabolism at transcriptional level are largely unknown. We profiled hepatic gene expression in adiponectin knockout (KO) and wild-type (WT) mice by RNA sequencing. Compared with WT mice, adiponectin KO mice fed a chow diet exhibited decreased mRNA expression of rate-limiting enzymes in several important glucose and lipid metabolic pathways, including glycolysis, tricarboxylic acid cycle, fatty-acid activation and synthesis, triglyceride sy...    »
 
Zeitschriftentitel:
Proc Natl Acad Sci U S A 
Jahr:
2012 
Band / Volume:
109 
Heft / Issue:
36 
Seitenangaben Beitrag:
14568-73 
Sprache:
eng 
Print-ISSN:
0027-8424 
TUM Einrichtung:
r Klinische Chemie und Pathobiochemie