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Dokumenttyp:
journal article 
Autor(en):
Shan, B; Schaaf, C; Schmidt, A; Lucia, K; Buchfelder, M; Losa, M; Kuhlen, D; Kreutzer, J; Perone, MJ; Arzt, E; Stalla, GK; Renner, U 
Titel:
Curcumin suppresses HIF1A synthesis and VEGFA release in pituitary adenomas. 
Abstract:
Curcumin (diferuloylmethane), a polyphenolic compound derived from the spice plant Curcuma longa, displays multiple actions on solid tumours including anti-angiogenic effects. Here we have studied in rodent and human pituitary tumour cells the influence of curcumin on the production of hypoxia inducible factor 1? (HIF1A) and vascular endothelial growth factor A (VEGFA), two key components involved in tumour neovascularisation through angiogenesis. Curcumin dose-dependently inhibited basal VEGFA...    »
 
Zeitschriftentitel:
J Endocrinol 
Jahr:
2012 
Band / Volume:
214 
Heft / Issue:
Seitenangaben Beitrag:
389-98 
Sprache:
eng 
Print-ISSN:
0022-0795 
TUM Einrichtung:
r Klinische Chemie und Pathobiochemie; Neurochirurgische Klinik und Poliklinik