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Document type:
journal article 
Author(s):
Shan, B; Schaaf, C; Schmidt, A; Lucia, K; Buchfelder, M; Losa, M; Kuhlen, D; Kreutzer, J; Perone, MJ; Arzt, E; Stalla, GK; Renner, U 
Title:
Curcumin suppresses HIF1A synthesis and VEGFA release in pituitary adenomas. 
Abstract:
Curcumin (diferuloylmethane), a polyphenolic compound derived from the spice plant Curcuma longa, displays multiple actions on solid tumours including anti-angiogenic effects. Here we have studied in rodent and human pituitary tumour cells the influence of curcumin on the production of hypoxia inducible factor 1? (HIF1A) and vascular endothelial growth factor A (VEGFA), two key components involved in tumour neovascularisation through angiogenesis. Curcumin dose-dependently inhibited basal VEGFA...    »
 
Journal title abbreviation:
J Endocrinol 
Year:
2012 
Journal volume:
214 
Journal issue:
Pages contribution:
389-98 
Language:
eng 
Print-ISSN:
0022-0795 
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie ; Neurochirurgische Klinik und Poliklinik