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Document type:
journal article 
Author(s):
Heindl, S; Eggenstein, E; Keller, S; Kneissl, J; Keller, G; Mutze, K; Rauser, S; Gasteiger, G; Drexler, I; Hapfelmeier, A; Höfler, H; Luber, B 
Title:
Relevance of MET activation and genetic alterations of KRAS and E-cadherin for cetuximab sensitivity of gastric cancer cell lines. 
Abstract:
The therapeutic activity of the epidermal growth factor receptor (EGFR)-directed monoclonal antibody cetuximab in gastric cancer is currently being investigated. Reliable biomarkers for the identification of patients who are likely to benefit from the treatment are not available. The aim of the study was to examine the drug sensitivity of five gastric cancer cell lines towards cetuximab as a single agent and to establish predictive markers for chemosensitivity in this cell culture model. The eff...    »
 
Journal title abbreviation:
J Cancer Res Clin Oncol 
Year:
2012 
Journal volume:
138 
Journal issue:
Pages contribution:
843-58 
Language:
eng 
Print-ISSN:
0171-5216 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie ; Institut für Virologie ; Institut für Medizinische Statistik und Epidemiologie