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Document type:
journal article 
Author(s):
Hatzichristodoulou, G; Kübler, H; Schwaibold, H; Wagenpfeil, S; Eibauer, C; Hofer, C; Gschwend, J; Treiber, U 
Title:
Nuclear matrix protein 22 for bladder cancer detection: comparative analysis of the BladderChek® and ELISA. 
Abstract:
To compare nuclear matrix protein 22 expression by BladderChek® and ELISA, as urine-based assays for bladder cancer (BC) detection.Urine samples of 100 BC patients and 100 controls were analyzed. Comparative statistical evaluations were based on sensitivity and specificity.Seventy-one patients had primary and 29 recurrent BC. The sensitivity of BladderChek® was significantly higher compared to ELISA in the overall cancer cohort and in patients with primary BC (p<0.0001 and p=0.0001, respectively). Both tests demonstrated significant correlation of sensitivities and tumor stage/grade for the overall cancer cohort and for patients with primary BC. Both tests had specificity values of 100% in healthy individuals. Specificity was 93% for BladderChek® and 99% for ELISA in patients with benign diseases (p=0.048).BladderChek® may be clinically more useful for BC detection. Due to high specificity, BladderChek® could be used for high-risk screening. However, due to its low sensitivity, BladderChek® cannot replace but only complement cystoscopy for BC detection. 
Journal title abbreviation:
Anticancer Res 
Year:
2012 
Journal volume:
32 
Journal issue:
11 
Pages contribution:
5093-7 
Language:
eng 
Print-ISSN:
0250-7005 
TUM Institution:
Urologische Klinik und Poliklinik; r Medizinische Statistik und Epidemiologie