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Dokumenttyp:
journal article 
Autor(en):
Illert, AL; Kawaguchi, H; Antinozzi, C; Bassermann, F; Quintanilla-Martinez, L; von Klitzing, C; Hiwatari, M; Peschel, C; de Rooij, DG; Morris, SW; Barchi, M; Duyster, J 
Titel:
Targeted inactivation of nuclear interaction partner of ALK disrupts meiotic prophase. 
Abstract:
NIPA (nuclear interaction partner of ALK) is an F-box-like protein that monitors the timing of mitotic entry. Constitutively active NIPA delays mitotic entry by preventing accumulation of nuclear cyclin B1. Here, we have investigated the consequences of Nipa inactivation by using a conditional knockout strategy. Nipa-deficient animals are viable but show a lower birth rate and reduced body weight. Furthermore, Nipa-deficient males are sterile owing to a block of spermatogenesis during meiotic pr...    »
 
Zeitschriftentitel:
Development 
Jahr:
2012 
Band / Volume:
139 
Heft / Issue:
14 
Seitenangaben Beitrag:
2523-34 
Sprache:
eng 
Print-ISSN:
0950-1991 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik