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Document type:
journal article 
Author(s):
Eisenächer, K; Krug, A 
Title:
Regulation of RLR-mediated innate immune signaling--it is all about keeping the balance. 
Abstract:
The current view of cytoplasmic RNA-mediated innate immune signaling involves the differential activation of the RNA helicases retinoic acid-inducible gene 1 (RIG-I), melanoma differentiation-associated gene 5 (MDA5) and laboratory of genetics and physiology-2 (LGP2) by distinct RNA viruses. RIG-I, MDA5 and LGP2 form the RIG-I like receptor family (RLR). Since the initial characterization of the RLRs rapid progress has been made in the understanding of the molecular mechanisms that upon virus in...    »
 
Journal title abbreviation:
Eur J Cell Biol 
Year:
2012 
Journal volume:
91 
Journal issue:
Pages contribution:
36-47 
Language:
eng 
Print-ISSN:
0171-9335 
TUM Institution:
II. Medizinische Klinik und Poliklinik