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Dokumenttyp:
journal article 
Autor(en):
Mayr, M; Becker, K; Schulte, N; Belle, S; Hofheinz, R; Krause, A; Schmid, RM; Röcken, C; Ebert, MP 
Titel:
Phase I study of imatinib, cisplatin and 5-fluoruracil or capecitabine in advanced esophageal and gastric adenocarcinoma. 
Abstract:
Despite all benefit provided by established therapies prognosis of gastric cancer remains poor. Targeted inhibition of platelet derived growth factor receptor (PDGFR) by imatinib may influence tumor growth and amplify chemotherapeutic effects.This phase I study evaluated dose limiting toxicity (DLT) of imatinib combinated with chemotherapy according to a 3-patient cohort dose-escalating design. Thirty-five patients received cisplatin (60 mg/m(2) d1 q 3w)/ capecitabine (1250 mg/m(2) bid d1-14 q 2...    »
 
Zeitschriftentitel:
BMC Cancer 
Jahr:
2012 
Band / Volume:
12 
Seitenangaben Beitrag:
587 
Sprache:
eng 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik; r Allgemeine Pathologie und pathologische Anatomie