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Document type:
journal article 
Author(s):
Jung, CB; Moretti, A; Mederos y Schnitzler, M; Iop, L; Storch, U; Bellin, M; Dorn, T; Ruppenthal, S; Pfeiffer, S; Goedel, A; Dirschinger, RJ; Seyfarth, M; Lam, JT; Sinnecker, D; Gudermann, T; Lipp, P; Laugwitz, KL 
Title:
Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia. 
Abstract:
Coordinated release of calcium (Ca(2+) ) from the sarcoplasmic reticulum (SR) through cardiac ryanodine receptor (RYR2) channels is essential for cardiomyocyte function. In catecholaminergic polymorphic ventricular tachycardia (CPVT), an inherited disease characterized by stress-induced ventricular arrhythmias in young patients with structurally normal hearts, autosomal dominant mutations in RYR2 or recessive mutations in calsequestrin lead to aberrant diastolic Ca(2+) release from the SR causin...    »
 
Journal title abbreviation:
EMBO Mol Med 
Year:
2012 
Journal volume:
Journal issue:
Pages contribution:
180-91 
Language:
eng 
Print-ISSN:
1757-4676 
TUM Institution:
I. Medizinische Klinik und Poliklinik