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Document type:
Journal Article; Article
Author(s):
Knopf, A; Mansour, N; Chaker, A; Bas, M; Stock, K
Title:
Multimodal ultrasonographic characterisation of parotid gland lesions--a pilot study.
Abstract:
Lesions of the major salivary glands represent a heterogeneous group comprising infectious, autoimmune, and neoplastic disorders. The reliable pre-operative assessment of the lesional dignity might reduce patient's morbidity preventing re-surgery. To date, there exists no imaging technique which reliably distinguishes tumour entities.35 parotid lesions were analysed in this study. B-mode ultrasound, colour duplex imaging and contrast enhanced ultrasound were applied for all patients. After fractionated boli of 4.8 ml SonoVue® perfusion kinetics, time to peak (TP) and mean transit time (MTT), were analysed for intraparotideal lesion and were normalised by circumjacent parotid tissue. Ultrasonographic data was structured in a multimodal diagnostic pathway.B-mode ultrasound identifies six lymphoepithelial lesions due to Sjoegren's syndrome (p: 0.0001). CDS further differentiates hypovascularised pleomorphic adenoma from hypervascularised Warthin's tumours, monomorphic adenomas, and carcinomas (p<0.0001). Application of CEUS detected Warthin's tumours being significantly hypervascularised compared to monomorphic adenomas (MTT, p<0.05) and carcinomas (MTT, p<0.02).A multimodal diagnostic pathway unifies different ultrasonographic techniques and identifies pleomorphic adenomas, Warthin's tumours and carcinomas with sensitivities of 100%. Further studies have to be performed to validate this diagnostic approach and to specify monomorphic adenomas.
Journal title abbreviation:
Eur J Radiol
Year:
2012
Journal volume:
81
Journal issue:
11
Pages contribution:
3300-5
Language:
eng
Fulltext / DOI:
doi:10.1016/j.ejrad.2012.01.004
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22269165
Print-ISSN:
0720-048X
TUM Institution:
Fachgebiet Nephrologie (Prof. Heemann); Hals-Nasen-Ohrenklinik und Poliklinik
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