Ghoussaini, M; Fletcher, O; Michailidou, K; Turnbull, C; Schmidt, MK; Dicks, E; Dennis, J; Wang, Q; Humphreys, MK; Luccarini, C; Baynes, C; Conroy, D; Maranian, M; Ahmed, S; Driver, K; Johnson, N; Orr, N; Dos Santos Silva, I; Waisfisz, Q; Meijers-Heijboer, H; Uitterlinden, AG; Rivadeneira, F; Hall, P; Czene, K; Irwanto, A; Liu, J; Nevanlinna, H; Aittomäki, K; Blomqvist, C; Meindl, A; Schmutzler, RK; Müller-Myhsok, B; Lichtner, P; Chang-Claude, J; Hein, R; Nickels, S; Flesch-Janys, D; Tsimiklis, H; Makalic, E; Schmidt, D; Bui, M; Hopper, JL; Apicella, C; Park, DJ; Southey, M; Hunter, DJ; Chanock, SJ; Broeks, A; Verhoef, S; Hogervorst, FB; Fasching, PA; Lux, MP; Beckmann, MW; Ekici, AB; Sawyer, E; Tomlinson, I; Kerin, M; Marme, F; Schneeweiss, A; Sohn, C; Burwinkel, B; Guénel, P; Truong, T; Cordina-Duverger, E; Menegaux, F; Bojesen, SE; Nordestgaard, BG; Nielsen, SF; Flyger, H; Milne, RL; Alonso, MR; González-Neira, A; Benitez, J; Anton-Culver, H; Ziogas, A; Bernstein, L; Dur, CC; Brenner, H; Muller, H; Arndt, V; Stegmaier, C; Justenhoven, C; Brauch, H; Bruning, T; Wang-Gohrke, S; Eilber, U; Dörk, T; Schürmann, P; Bremer, M; Hillemanns, P; Bogdanova, NV; Antonenkova, NN; Rogov, YI; Karstens, JH; Bermisheva, M; Prokofieva, D; Khusnutdinova, E; Lindblom, A; Margolin, S; Mannermaa, A; Kataja, V; Kosma, VM; Hartikainen, JM; Lambrechts, D; Yesilyurt, BT; Floris, G; Leunen, K; Manoukian, S; Bonanni, B; Fortuzzi, S; Peterlongo, P; Couch, FJ; Wang, X; Stevens, K; Lee, A; Giles, GG; Baglietto, L; Severi, G; McLean, C; Alnaes, GG; Kristensen, V; Børrensen-Dale, AL; John, EM; Miron, A; Winqvist, R; Pylkäs, K; Jukkola-Vuorinen, A; Kauppila, S; Andrulis, IL; Glendon, G; Mulligan, AM; Devilee, P; van Asperen, CJ; Tollenaar, RA; Seynaeve, C; Figueroa, JD; Garcia-Closas, M; Brinton, L; Lissowska, J; Hooning, MJ; Hollestelle, A; Oldenburg, RA; van den Ouweland, AM; Cox, A; Reed, MW; Shah, M; Jakubowska, A; Lubinski, J; Jaworska, K; Durda, K; Jones, M; Schoemaker, M; Ashworth, A; Swerdlow, A; Beesley, J; Chen, X; Muir, KR; Lophatananon, A; Rattanamongkongul, S; Chaiwerawattana, A; Kang, D; Yoo, KY; Noh, DY; Shen, CY; Yu, JC; Wu, PE; Hsiung, CN; Perkins, A; Swann, R; Velentzis, L; Eccles, DM; Tapper, WJ; Gerty, SM; Graham, NJ; Ponder, BA; Chenevix-Trench, G; Pharoah, PD; Lathrop, M; Dunning, AM; Rahman, N; Peto, J; Easton, DF     «

Ghoussaini, M; Fletcher, O; Michailidou, K; Turnbull, C; Schmidt, MK; Dicks, E; Dennis, J; Wang, Q; Humphreys, MK; Luccarini, C; Baynes, C; Conroy, D; Maranian, M; Ahmed, S; Driver, K; Johnson, N; Orr, N; Dos Santos Silva, I; Waisfisz, Q; Meijers-Heijboer, H; Uitterlinden, AG; Rivadeneira, F; Hall, P; Czene, K; Irwanto, A; Liu, J; Nevanlinna, H; Aittomäki, K; Blomqvist, C; Meindl, A; Schmutzler, RK; Müller-Myhsok, B; Lichtner, P; Chang-Claude, J; Hein, R; Nickels, S; Flesch-Janys, D; Tsimiklis,...     »

Breast cancer is the most common cancer among women. To date, 22 common breast cancer susceptibility loci have been identified accounting for ~8% of the heritability of the disease. We attempted to replicate 72 promising associations from two independent genome-wide association studies (GWAS) in ~70,000 cases and ~68,000 controls from 41 case-control studies and 9 breast cancer GWAS. We identified three new breast cancer risk loci at 12p11 (rs10771399; P = 2.7 × 10(-35)), 12q24 (rs1292011; P = 4.3 × 10(-19)) and 21q21 (rs2823093; P = 1.1 × 10(-12)). rs10771399 was associated with similar relative risks for both estrogen receptor (ER)-negative and ER-positive breast cancer, whereas the other two loci were associated only with ER-positive disease. Two of the loci lie in regions that contain strong plausible candidate genes: PTHLH (12p11) has a crucial role in mammary gland development and the establishment of bone metastasis in breast cancer, and NRIP1 (21q21) encodes an ER cofactor and has a role in the regulation of breast cancer cell growth.     «

Breast cancer is the most common cancer among women. To date, 22 common breast cancer susceptibility loci have been identified accounting for ~8% of the heritability of the disease. We attempted to replicate 72 promising associations from two independent genome-wide association studies (GWAS) in ~70,000 cases and ~68,000 controls from 41 case-control studies and 9 breast cancer GWAS. We identified three new breast cancer risk loci at 12p11 (rs10771399; P = 2.7 × 10(-35)), 12q24 (rs1292011; P =...     »