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Document type:
journal article 
Author(s):
Ghoussaini, M; Fletcher, O; Michailidou, K; Turnbull, C; Schmidt, MK; Dicks, E; Dennis, J; Wang, Q; Humphreys, MK; Luccarini, C; Baynes, C; Conroy, D; Maranian, M; Ahmed, S; Driver, K; Johnson, N; Orr, N; dos Santos Silva, I; Waisfisz, Q; Meijers-Heijboer, H; Uitterlinden, AG; Rivadeneira, F; Netherlands Collaborative Group on Hereditary Breast and Ovarian Cancer (HEBON); Hall, P; Czene, K; Irwanto, A; Liu, J; Nevanlinna, H; Aittomäki, K; Blomqvist, C; Meindl, A; Schmutzler, RK; Müller-Myhsok, B...    »
 
Title:
Genome-wide association analysis identifies three new breast cancer susceptibility loci. 
Abstract:
Breast cancer is the most common cancer among women. To date, 22 common breast cancer susceptibility loci have been identified accounting for ~8% of the heritability of the disease. We attempted to replicate 72 promising associations from two independent genome-wide association studies (GWAS) in ~70,000 cases and ~68,000 controls from 41 case-control studies and 9 breast cancer GWAS. We identified three new breast cancer risk loci at 12p11 (rs10771399; P = 2.7 × 10(-35)), 12q24 (rs1292011; P =...    »
 
Journal title abbreviation:
Nat Genet 
Year:
2012 
Journal volume:
44 
Journal issue:
Pages contribution:
312-8 
Language:
eng 
Print-ISSN:
1061-4036 
TUM Institution:
Frauenklinik und Poliklinik