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Dokumenttyp:
journal article 
Autor(en):
Mavaddat, N; Barrowdale, D; Andrulis, IL; Domchek, SM; Eccles, D; Nevanlinna, H; Ramus, SJ; Spurdle, A; Robson, M; Sherman, M; Mulligan, AM; Couch, FJ; Engel, C; McGuffog, L; Healey, S; Sinilnikova, OM; Southey, MC; Terry, MB; Goldgar, D; O'Malley, F; John, EM; Janavicius, R; Tihomirova, L; Hansen, TV; Nielsen, FC; Osorio, A; Stavropoulou, A; Benítez, J; Manoukian, S; Peissel, B; Barile, M; Volorio, S; Pasini, B; Dolcetti, R; Putignano, AL; Ottini, L; Radice, P; Hamann, U; Rashid, MU; Hogervorst...    »
 
Titel:
Pathology of breast and ovarian cancers among BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). 
Abstract:
Previously, small studies have found that BRCA1 and BRCA2 breast tumors differ in their pathology. Analysis of larger datasets of mutation carriers should allow further tumor characterization.We used data from 4,325 BRCA1 and 2,568 BRCA2 mutation carriers to analyze the pathology of invasive breast, ovarian, and contralateral breast cancers.There was strong evidence that the proportion of estrogen receptor (ER)-negative breast tumors decreased with age at diagnosis among BRCA1 (P-trend = 1.2 × 1...    »
 
Zeitschriftentitel:
Cancer Epidemiol Biomarkers Prev 
Jahr:
2012 
Band / Volume:
21 
Heft / Issue:
Seitenangaben Beitrag:
134-47 
Sprache:
eng 
Print-ISSN:
1055-9965 
TUM Einrichtung:
Frauenklinik und Poliklinik