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Document type:
journal article 
Author(s):
Loessner, D; Quent, VM; Kraemer, J; Weber, EC; Hutmacher, DW; Magdolen, V; Clements, JA 
Title:
Combined expression of KLK4, KLK5, KLK6, and KLK7 by ovarian cancer cells leads to decreased adhesion and paclitaxel-induced chemoresistance. 
Abstract:
Chemoresistance is a critical feature of advanced ovarian cancer with only 30% of patients surviving longer than 5 years. We have previously shown that four kallikrein-related (KLK) peptidases, KLK4, KLK5, KLK6 and KLK7 (KLK4-7), are implicated in peritoneal invasion and tumour growth, but underlying mechanisms were not identified. We also reported that KLK7 overexpression confers chemoresistance to paclitaxel, and cell survival via integrins. In this study, we further explored the functional co...    »
 
Journal title abbreviation:
Gynecol Oncol 
Year:
2012 
Journal volume:
127 
Journal issue:
Pages contribution:
569-78 
Language:
eng 
Print-ISSN:
0090-8258 
TUM Institution:
Frauenklinik und Poliklinik