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Dokumenttyp:
journal article 
Autor(en):
Meier, W; du Bois, A; Rau, J; Gropp-Meier, M; Baumann, K; Huober, J; Wollschlaeger, K; Kreienberg, R; Canzler, U; Schmalfeldt, B; Wimberger, P; Richter, B; Schröder, W; Belau, A; Stähle, A; Burges, A; Sehouli, J 
Titel:
Randomized phase II trial of carboplatin and paclitaxel with or without lonafarnib in first-line treatment of epithelial ovarian cancer stage IIB-IV. 
Abstract:
This study evaluates whether a molecular targeted therapy with the farnesyltransferase inhibitor lonafarnib added to standard chemotherapy in first-line treatment of advanced ovarian cancer (OC) could improve progression-free (PFS) and overall survival (OS).We performed a prospective randomized phase II study to compare standard therapy carboplatin (C; AUC 5) and paclitaxel (T; 175 mg/m(2)) in primary advanced OC with or without lonafarnib (L). Lonafarnib was given in a dose of 100mg orally tw...    »
 
Zeitschriftentitel:
Gynecol Oncol 
Jahr:
2012 
Band / Volume:
126 
Heft / Issue:
Seitenangaben Beitrag:
236-40 
Sprache:
eng 
Print-ISSN:
0090-8258 
TUM Einrichtung:
Frauenklinik und Poliklinik