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Document type:
journal article 
Author(s):
Rzymski, T; Petry, A; Kra?un, D; Rieß, F; Pike, L; Harris, AL; Görlach, A 
Title:
The unfolded protein response controls induction and activation of ADAM17/TACE by severe hypoxia and ER stress. 
Abstract:
The family of ADAM (a disintegrin and metalloproteinase) proteins has been implicated in tumor initiation and progression. ADAM17/tumor necrosis factor-? (TNF?)-converting enzyme (TACE) has been initially recognized to release TNF? as well as its receptors (TNFRs) from the membrane. ADAM17, TNF? and TNFR have been found upregulated in cancer patients, although the underlying mechanisms remain largely unknown. As hypoxia is a hallmark of cancer that can lead to severe stress conditions accumulati...    »
 
Journal title abbreviation:
Oncogene 
Year:
2012 
Journal volume:
31 
Journal issue:
31 
Pages contribution:
3621-34 
Language:
eng 
Print-ISSN:
0950-9232 
TUM Institution:
Klinik für Kinderkardiologie und angeborene Herzfehler