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Document type:
journal article 
Author(s):
Petry, A; BelAiba, RS; Weitnauer, M; Görlach, A 
Title:
Inhibition of endothelial nitric oxyde synthase increases capillary formation via Rac1-dependent induction of hypoxia-inducible factor-1? and plasminogen activator inhibitor-1. 
Abstract:
Disruption of endothelial homeostasis results in endothelial dysfunction, characterised by a dysbalance between nitric oxide (NO) and reactive oxygen species (ROS) levels often accompanied by a prothrombotic and proproliferative state. The serine protease thrombin not only is instrumental in formation of the fibrin clot, but also exerts direct effects on the vessel wall by activating proliferative and angiogenic responses. In endothelial cells, thrombin can induce NO as well as ROS levels. Howev...    »
 
Journal title abbreviation:
Thromb Haemost 
Year:
2012 
Journal volume:
108 
Journal issue:
Pages contribution:
849-62 
Language:
eng 
Print-ISSN:
0340-6245 
TUM Institution:
Klinik für Kinderkardiologie und angeborene Herzfehler