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Dokumenttyp:
journal article 
Autor(en):
Wenzel, V; Roedl, D; Gabriel, D; Gordon, LB; Herlyn, M; Schneider, R; Ring, J; Djabali, K 
Titel:
Naïve adult stem cells from patients with Hutchinson-Gilford progeria syndrome express low levels of progerin in vivo. 
Abstract:
Hutchinson-Gilford progeria syndrome (HGPS, OMIM 176670) is a rare disorder characterized by segmental accelerated aging and early death from coronary artery disease or stroke. Nearly 90% of HGPS sufferers carry a G608G mutation within exon 11 of LMNA, producing a truncated form of prelamin A, referred to as "progerin". Here, we report the isolation of naïve multipotent skin-derived precursor (SKP) cells from dermal fibroblast cultures from HGPS donors. These cells form spheres and express the n...    »
 
Zeitschriftentitel:
Biol Open 
Jahr:
2012 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
516-26 
Sprache:
eng 
TUM Einrichtung:
r Dermatologie und Allergologie