User: Guest  Login
Document type:
journal article 
Author(s):
Wang, J; Sun, Q; Morita, Y; Jiang, H; Gross, A; Lechel, A; Hildner, K; Guachalla, LM; Gompf, A; Hartmann, D; Schambach, A; Wuestefeld, T; Dauch, D; Schrezenmeier, H; Hofmann, WK; Nakauchi, H; Ju, Z; Kestler, HA; Zender, L; Rudolph, KL 
Title:
A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage. 
Abstract:
Checkpoints that limit stem cell self-renewal in response to DNA damage can contribute to cancer protection but may also promote tissue aging. Molecular components that control stem cell responses to DNA damage remain to be delineated. Using in vivo RNAi screens, we identified basic leucine zipper transcription factor, ATF-like (BATF) as a major component limiting self-renewal of hematopoietic stem cells (HSCs) in response to telomere dysfunction and ?-irradiation. DNA damage induces BATF in a G...    »
 
Journal title abbreviation:
Cell 
Year:
2012 
Journal volume:
148 
Journal issue:
Pages contribution:
1001-14 
Language:
eng 
Print-ISSN:
0092-8674 
TUM Institution:
Chirurgiesche Klinik und Poliklinik