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Dokumenttyp:
journal article 
Autor(en):
Katz, SF; Lechel, A; Obenauf, AC; Begus-Nahrmann, Y; Kraus, JM; Hoffmann, EM; Duda, J; Eshraghi, P; Hartmann, D; Liss, B; Schirmacher, P; Kestler, HA; Speicher, MR; Rudolph, KL 
Titel:
Disruption of Trp53 in livers of mice induces formation of carcinomas with bilineal differentiation. 
Abstract:
p53 limits the self-renewal of stem cells from various tissues. Loss of p53, in combination with other oncogenic events, results in aberrant self-renewal and transformation of progenitor cells. It is not known whether loss of p53 is sufficient to induce tumor formation in liver.We used AlfpCre mice to create mice with liver-specific disruption of Trp53 (AlfpCre(+)Trp53(?2-10/?2-10) mice). We analyzed colony formation and genomic features and gene expression patterns in liver cells during hepatoc...    »
 
Zeitschriftentitel:
Gastroenterology 
Jahr:
2012 
Band / Volume:
142 
Heft / Issue:
Seitenangaben Beitrag:
1229-1239.e3 
Sprache:
eng 
Print-ISSN:
0016-5085 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik