Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Jusek, G; Reim, D; Tsujikawa, K; Holzmann, B 
Titel:
Deficiency of the CGRP receptor component RAMP1 attenuates immunosuppression during the early phase of septic peritonitis. 
Abstract:
The neuropeptide CGRP contributes to the control of excessive cytokine production in endotoxemia models. However, the function of CGRP in sepsis caused by infection with viable pathogens is unknown. Here, we show that mice deficient for the CGRP receptor component RAMP1 have an improved anti-bacterial defense during the early, but not late, phase of polymicrobial septic peritonitis. The protective effect of Ramp1-deficiency was associated with reduced levels of IL-10 in plasma and peritoneal lav...    »
 
Zeitschriftentitel:
Immunobiology 
Jahr:
2012 
Band / Volume:
217 
Heft / Issue:
Seitenangaben Beitrag:
761-7 
Sprache:
eng 
Print-ISSN:
0171-2985 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik