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Dokumenttyp:
journal article 
Autor(en):
Zeestraten, EC; Maak, M; Shibayama, M; Schuster, T; Nitsche, U; Matsushima, T; Nakayama, S; Gohda, K; Friess, H; van de Velde, CJ; Ishihara, H; Rosenberg, R; Kuppen, PJ; Janssen, KP 
Titel:
Specific activity of cyclin-dependent kinase I is a new potential predictor of tumour recurrence in stage II colon cancer. 
Abstract:
There are no established biomarkers to identify tumour recurrence in stage II colon cancer. As shown previously, the enzymatic activity of the cyclin-dependent kinases 1 and 2 (CDK1 and CDK2) predicts outcome in breast cancer. Therefore, we investigated whether CDK activity identifies tumour recurrence in colon cancer.In all, 254 patients with completely resected (R0) UICC stage II colon cancer were analysed retrospectively from two independent cohorts from Munich (Germany) and Leiden (Netherlan...    »
 
Zeitschriftentitel:
Br J Cancer 
Jahr:
2012 
Band / Volume:
106 
Heft / Issue:
Seitenangaben Beitrag:
133-40 
Sprache:
eng 
Print-ISSN:
0007-0920 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik; r Medizinische Statistik und Epidemiologie