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Document type:
journal article 
Author(s):
Quinton, LJ; Blahna, MT; Jones, MR; Allen, E; Ferrari, JD; Hilliard, KL; Zhang, X; Sabharwal, V; Algül, H; Akira, S; Schmid, RM; Pelton, SI; Spira, A; Mizgerd, JP 
Title:
Hepatocyte-specific mutation of both NF-?B RelA and STAT3 abrogates the acute phase response in mice. 
Abstract:
The acute phase response is an evolutionarily conserved reaction in which physiological stress triggers the liver to remodel the blood proteome. Although thought to be involved in immune defense, the net biological effect of the acute phase response remains unknown. As the acute phase response is stimulated by diverse cytokines that activate either NF-?B or STAT3, we hypothesized that it could be eliminated by hepatocyte-specific interruption of both transcription factors. Here, we report that t...    »
 
Journal title abbreviation:
J Clin Invest 
Year:
2012 
Journal volume:
122 
Journal issue:
Pages contribution:
1758-63 
Language:
eng 
Print-ISSN:
0021-9738 
TUM Institution:
II. Medizinische Klinik und Poliklinik