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Document type:
journal article 
Author(s):
Hamidi, T; Algül, H; Cano, CE; Sandi, MJ; Molejon, MI; Riemann, M; Calvo, EL; Lomberk, G; Dagorn, JC; Weih, F; Urrutia, R; Schmid, RM; Iovanna, JL 
Title:
Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis. 
Abstract:
Pancreatic ductal adenocarcinoma (PDAC) has the lowest survival rate of all cancers and shows remarkable resistance to cell stress. Nuclear protein 1 (Nupr1), which mediates stress response in the pancreas, is frequently upregulated in pancreatic cancer. Here, we report that Nupr1 plays an essential role in pancreatic tumorigenesis. In a mouse model of pancreatic cancer with constitutively expressed oncogenic Kras(G12D), we found that loss of Nupr1 protected from the development of pancreatic in...    »
 
Journal title abbreviation:
J Clin Invest 
Year:
2012 
Journal volume:
122 
Journal issue:
Pages contribution:
2092-103 
Language:
eng 
Print-ISSN:
0021-9738 
TUM Institution:
II. Medizinische Klinik und Poliklinik