A joint project by the Chair for Medical Engineering of the Technical University of Munich, Krones AG, Neutraubling, and the Innovation Center for Therapeutic Medical Technology (ITEM GmbH ) was conducted to prove the suitability of stretch blow molded PET bottles, which are already used for beverages, for primary packaging for enternal and parenternal nutrition solutions. Stretch blow molded PET containers combine technical advantages, such as unbreakability, excellent gas barrier properties and low interactions with their contents, with an excellent cost efficiency. Chemical, physical an biological tests conducted at ITEM GmbH, revealed that the PET containers tested fulfilled all the requirements listed in the standards such as DIN EN ISO 15747 and DIN EN ISO 10993. An evaluation of these tests proved that PET containers can safely be used as primary packaging for enternal and parenternal nutrition solutions.     «

A joint project by the Chair for Medical Engineering of the Technical University of Munich, Krones AG, Neutraubling, and the Innovation Center for Therapeutic Medical Technology (ITEM GmbH ) was conducted to prove the suitability of stretch blow molded PET bottles, which are already used for beverages, for primary packaging for enternal and parenternal nutrition solutions. Stretch blow molded PET containers combine technical advantages, such as unbreakability, excellent gas barrier properties an...     »

Cited By (since 1996):1 Export Date: 24 October 2013 Source: Scopus References: Helbock, H.J., Motchnik, P.A., Ames, B.N., Toxic hydroperoxides in intravenous lipid emulsions used in preterm infants (1993) Pediatrics, 91, pp. 83-87; Rufian-Henares, J.A., Guerra-Hernandez, E., Garcia-Villanove, B., Evolution of fatty acid profile and lipid oxidation during enteral formula storage (2005) JPEN J Parenter Enteral Nutrition, 29, pp. 204-211; Bohrer, D., do Nascimento, P.C., Binotto, R., Martins, P., Availability of aluminium from glass and an Al form ion exchanger in the presence of complexing agents and amino acids (2002) Analytica Chimica Acta, 459, pp. 267-276; Feigal, D., (2002) Safety Assessment of Di(2-ethylhexyllphthalate (DEHP) Released from PVC medical Devices. Editor, , FDA; Sarbach, C., Yagoubi, N., Sauzieres, J., Migration of Impurities from a multilayer plastics container into a parenteral infusion fluid (1996) International Journal of Pharmaceutics, pp. 169-174; Allwood, M.C., Martin, H., The extraction of diethylhexylphthalate (DEHP) from Polyvinylchloride components of intravenous infusion containers and administration sets by paclitaxel injection (1996) International Journal of Pharmaceutics, pp. 65-71; Chaumeil, J. C.: Packaging: the guarantee of medicinal quality. Ann Pharm Fr 61, 2003, 304-7; Discussion, pp. 8-9DIN EN ISO 15747:2005 Kunststoffbehälter für intravenöse Injektionen, European Pharmacopeia 3.2.2.1 Plastic containers for aqueous solutions for parenteral use und US Pharmacopeia 〈661〉 (Testing of Containers (FDA: NEW 510(k) Paradigm)Seiffe, K., (2006) Validation of specific polymers on their adequacy as primary packaging for parenteral solutions, p. 37. , Master thesis TU München; Seiffe, K., Rietzel, D., Research papers at ITEM GmbH within the framework of the composite project OptiPETHan Wu; G.; Jarstand, C.; Nordenström. J.: Phagocyte-induced lipid peroxidation of different intravenous fat emulsions and counteractive effect of vitamin E. Nutrition, 15, 1999. pp. 359-364Pironi, L.; Guidetti, M.; Zolezzi, C.: Peroxidation potential of lipid emulsions after compounding in all-in-one solutions. Nutrition, 19, 2003, pp. 784-788Rietzel, D., (2006) Validierung ausgewählter Kunststoffe als Werkstoff für Primärverpackungen in der enteralen und parenteralen Ernährung, pp. 11-12. , Diploma thesis TU München; Rietzel, D., (2006) Validierung ausgewählter Kunststoffe als Werkstoff für Primärverpackungen in der enteralen und parenteralen Ernährung, p. 13. , Diploma thesis TU München     «

Cited By (since 1996):1 Export Date: 24 October 2013 Source: Scopus References: Helbock, H.J., Motchnik, P.A., Ames, B.N., Toxic hydroperoxides in intravenous lipid emulsions used in preterm infants (1993) Pediatrics, 91, pp. 83-87; Rufian-Henares, J.A., Guerra-Hernandez, E., Garcia-Villanove, B., Evolution of fatty acid profile and lipid oxidation during enteral formula storage (2005) JPEN J Parenter Enteral Nutrition, 29, pp. 204-211; Bohrer, D., do Nascimento, P.C., Binotto, R., Martins, P....     »