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Dokumenttyp:
Journal Article 
Autor(en):
Nodwell, M. B.; Menz, H.; Kirsch, S. F.; Sieber, S. A. 
Titel:
Rugulactone and its Analogues Exert Antibacterial Effects through Multiple Mechanisms Including Inhibition of Thiamine Biosynthesis 
Abstract:
Rugulactone is a dihydro-a-pyrone isolated from the plant Cryptocarya rugulosa in 2009. It has been reported to display IkB kinase (IKK) inhibitory activity, as well as antibiotic activity in several strains of pathogenic bacteria. However, its biological targets and mode of action in bacteria have not yet been explored. Here we present enantioselective syntheses of rugulactone and of some corresponding activity-based protein profiling (ABPP) probes. We found that the ABPP probes in this study a...    »
 
Kongresstitel:
ISI Document Delivery No.: 967XQ Times Cited: 2 Cited Reference Count: 43 Nodwell, Matthew B. Menz, Helge Kirsch, Stefan F. Sieber, Stephan A. Deutsche Forschungsgemeinschaft [SFB749, FOR1406]; ERC; Center for Integrated Protein Science, Munich (CIPSM); Alexander von Humboldt foundation We thank Mona Wolf for excellent scientific support and Max Pitcheider for the E. coli clones. We also thank Tadhg Begley for the kind gift of HMP. S. A. S. was supported by the Deutsche Forschungsgemeinschaft...    »
 
Zeitschriftentitel:
Chembiochem 
Jahr:
2012 
Band / Volume:
13 
Heft / Issue:
10 
Seitenangaben Beitrag:
1439-1446