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Original title:
Relationship between in-vivo [11C]PiB PET Signal and Amyloid-β Plaque Pathology in different transgenic Mouse Models of Alzheimer's Disease 
Translated title:
Verhältnis von in-vivo [11C]PiB PET Signal und Amyloid-β Plaque-Pathology in verschiedenen transgenen Mausmodellen der Alzheimer Krankheit 
Year:
2012 
Document type:
Dissertation 
Institution:
Fakultät für Medizin 
Advisor:
Drzezga, Alexander (Prof. Dr.) 
Referee:
Ziegler, Sibylle (Prof. Dr.); Beer, Ambros (Priv.-Doz. Dr.); Drzezga, Alexander (Prof. Dr.) 
Language:
en 
Subject group:
MED Medizin 
Keywords:
Amyloid-β, mouse model, transgenic, Alzheimer's disease, positron emission tomography, PET, PiB, Tg2576, ARTE10, APP, PS1, pyroglutamate, statistical parametric mapping, SPM, voxel 
Translated keywords:
Amyloid-β, Mausmodell, transgen, Alzheimer Krankheit, positron emissions tomography, PET, PiB, Tg2576, ARTE10, APP, PS1, Pyroglutamat, statistical parametric mapping, SPM, voxel 
Abstract:
The quantitative relationship between the in-vivo signal of amyloid-β (Aβ) positron emission tomography (PET) imaging with [11C]6-OH-BTA-1 (PiB) in transgenic mouse models of Alzheimer's disease and the underlying histopathology is so far ill-defined. In this study we compared a single transgenic APP (Tg2576) and a double transgenic APP/PS1 mouse model (ARTE10). We performed PiB PET imaging followed by an automated quantification of Aβ plaque histopathology using three different stainings: Thio...    »
 
Translated abstract:
Der quantitative Zusammenhang zwischen dem in-vivo Signal der Amyloid-β (Aβ) Bildgebung mittels Positronen-Emissions-Tomographie (PET) mit [11C]6-OH-BTA-1 (PiB) in transgenen Mausmodellen der Alzheimer Erkrankung und der zugrunde liegenden Histopathologie ist bisher nicht ausreichend geklärt. Diese Arbeit vergleicht ein einfach-transgenes APP (Tg2576) und ein doppelt-transgenes APP/PS1 Mausmodell (ARTE10). Nach einem PiB PET-Scan wurde mittels drei histologischer Färbungen die Aβ-Plaque-Patholog...    »
 
Oral examination:
25.09.2012 
File size:
2115719 bytes 
Pages:
97 
Last change:
29.01.2013