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Document type:
journal article 
Author(s):
Hasenpusch, G; Geiger, J; Wagner, K; Mykhaylyk, O; Wiekhorst, F; Trahms, L; Heidsieck, A; Gleich, B; Bergemann, C; Aneja, MK; Rudolph, C 
Title:
Magnetized aerosols comprising superparamagnetic iron oxide nanoparticles improve targeted drug and gene delivery to the lung. 
Abstract:
Targeted delivery of aerosols could not only improve efficacy of inhaled drugs but also reduce side effects resulting from their accumulation in healthy tissue. Here we investigated the impact of magnetized aerosols on model drug accumulation and transgene expression in magnetically targeted lung regions of unanesthetized mice.Solutions containing superparamagnetic iron oxide nanoparticles (SPIONs) and model drugs (fluorescein or complexed plasmid DNA) were nebulized to unanesthetized mice under...    »
 
Journal title abbreviation:
Pharm Res 
Year:
2012 
Journal volume:
29 
Journal issue:
Pages contribution:
1308-18 
Language:
eng 
Print-ISSN:
0724-8741 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung