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Document type:
journal article 
Author(s):
Trueck, C; Zimmermann, K; Mykhaylyk, O; Anton, M; Vosen, S; Wenzel, D; Fleischmann, BK; Pfeifer, A 
Title:
Optimization of magnetic nanoparticle-assisted lentiviral gene transfer. 
Abstract:
Targeting of specific cells and tissues is of great interest for clinical relevant gene- and cell-based therapies. We use magnetic nanoparticles (MNPs) with a ferrimagnetic core (Fe(3)O(4)) with different coatings to optimize MNP-assisted lentiviral gene transfer with focus on different endothelial cell lines.Lentiviral vector (LV)/MNP binding was characterized for various MNPs by different methods (e.g. magnetic responsiveness measurement). Transduced cells were analyzed by flow cytometry, fluo...    »
 
Journal title abbreviation:
Pharm Res 
Year:
2012 
Journal volume:
29 
Journal issue:
Pages contribution:
1255-69 
Language:
eng 
Print-ISSN:
0724-8741 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung